What Are MPNs?

Myeloproliferative Neoplasms (MPNs) are a group of rare, chronic blood cancers that affect the production of normal blood cells in the bone marrow. The most common MPNs are Essential Thrombocythaemia (ET), Polycythaemia Vera (PV) and Primary Myelofibrosis (PMF). MPNs usually occur in people over 60 years of age but are increasingly diagnosed in people under 40 years and occasionally in children.

In MPNs the bone marrow overproduces one or more types of blood cells (red cells, white cells or platelets). If not promptly diagnosed and effectively treated the excessive numbers of blood cells can cause serious and devastating complications, such as stroke and heart attack.

Early diagnosis, monitoring and therapy are crucial.